Supercoiled DNA is far more dynamic than the “Watson-Crick” double helix

Researchers have imaged in unprecedented detail the three-dimensional structure of supercoiled DNA, revealing that its shape is much more dynamic than the well-known double helix. As reported online today in the journal Nature Communications, the simulations also show the dynamic nature of DNA, which constantly wiggles and morphs into different shapes, a far cry from the commonly held idea of a rigid and static double helix. Improving our understanding of what DNA looks like when it is in the...
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Live imaging reveals how wound healing influences cancer

"See-through" larvae of zebrafish reveal how wound healing leads to skin cancer. Genetically modified larvae of zebrafish were studied by the researchers in the United Kingdom and Denmark   to watch the relationship between wound-associated inflammation and melanoma. The cellular events and changes were observed by live imaging with a special confocal laser-scanning microscope. The experiments showed that neutrophils, the protective inflammatory cells of the body's immune system, gets d...
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