A short exposure to an alternating magnetic field might someday replace multiple surgeries and weeks of IV antibiotics as treatment for stubborn infections on artificial joints, new research suggests.
Researchers at UT Southwestern Medical Center have shown that high-frequency alternating magnetic fields – the same principle used in induction cooktops – can be used to destroy bacteria that are encased in a slimy “biofilm” growing on a metal surface. The biofilm is a collection of microorganisms that stick to each other as well as to various surfaces. This aggregate of organisms and other substances that surround them makes it difficult for both drugs and immune cells to reach the bacteria.
Dr. Greenberg, Associate Professor of Internal Medicine and of Microbiology, said biofilm-related infections are one of the most serious complications of knee and hip replacements, often requiring multiple surgeries. “We were looking for better ways to target and treat biofilms. Our idea was to put a coil around the joint and run a current through it to create alternating magnetic fields. Human tissue isn’t conductive but metal is, so only the implant would heat up.”
Using prosthetic joint models, the researchers showed that heating the metal surface via AMFs destroyed biofilm and killed bacteria. They tested several species of bacteria that create biofilm on artificial joints, and the process worked with each type.
Another key finding of their work is that AMF treatment increased the effectiveness of antibiotic treatment. “Think about heat as a drug for a minute,” said Dr. Greenberg. “Sometimes in infectious diseases we want to know whether two drugs are synergistic, meaning one plus one equals four, which is the case with AMF and antibiotics. That’s important because if treatments are synergistic, you can use lower concentrations of each, which has implications for safety as well as cost.”
Mouse-model safety tests indicated that high-power, short-duration doses of AMF minimize heat damage to adjoining tissue. High power achieves a target temperature on the surface of the metal device quickly, before there is much time for heat to accumulate in surrounding tissues.
Each year, more than 1 million knee and hip replacements are performed in the United States, and the numbers are expected to rise dramatically over the next decade with rising rates of obesity and an aging population.
While prosthetic joint infection rates are low, when they do occur they are exceptionally difficult to treat. Current treatment for an infection in a prosthetic knee involves removal of the biofilm-covered joint, placement of a temporary spacer, a six-week course of intravenous antibiotics, and then a second knee-replacement surgery that’s more complex to perform than the original surgery.
Patients are unable to take part in normal activities for months.
“Periprosthetic joint infections are a devastating complication to patients and are a significant financial burden to our health care system,” said orthopaedic surgeon Dr. Kenneth Estrera, an Assistant Professor at UT Southwestern. “The research by Dr. Greenberg and Dr. Chopra may lead to a solution to the most challenging problem in joint arthroplasty surgery.”
Future work includes more animal-model tests of safety and effectiveness.
Other UT Southwestern researchers who contributed to this project are Sumbul Shaikh, research assistant; Yonatan Chatzinoff, biomedical engineering specialist; Dr. Imalka Munaweera, post-doctoral researcher; Dr. Bingbing Cheng, post-doctoral researcher; Dr. Seth M. Daly, post-doctoral researcher; Dr. Yin Xi, Assistant Professor of Radiology and of the Department of Clinical Sciences; Chenchen Bing, research associate; and Dr. Dennis Burns, Professor of Pathology and holder of the Jane B. and Edwin P. Jenevein, M.D. Chair in Pathology.
How high frequency alternating magnetic fields work
- Electrical current running through a wire creates a magnetic field. When the wire is coiled, the magnetic field is concentrated in the center of the coil.
- The direction of the magnetic field – the north/south orientation – depends on the direction of the flow of the electricity. When the direction of the current is reversed, the direction of the magnetic field reverses.
- Running a high-frequency (greater than 100 kHz) alternating current through a coil will cause the surface of metal objects within the coil to rapidly heat.
- This is the same principle used in induction cooktops to heat the pot that boils the water.